Senior Principal Scientist, Discovery Oncology

At Roche you can show up as yourself, embraced for the unique qualities you bring.

Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.

This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.

Join Roche, where every voice matters.

The Position

In Roche´s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs.

At pRED, we are united by our mission to transform science into medicine.

Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located within our Discovery Research Units within the Oncology Discovery organization dedicated to the discovery and development of novel cancer therapeutics.

We collaborate closely with functions in Therapeutic Modalities and Pharmaceutical Science, as well as within the oncology therapeutic area, to translate hypotheses into innovative therapeutics. 

The Opportunity

As a Senior Principal Scientist in Discovery Oncology, you'll drive cutting-edge cancer drug discovery programs through essential preclinical research.

Your primary responsibilities include mentoring a team of scientists, associates, students, and postdocs, and translating basic research into therapeutic strategies.

You will focus on understanding target mechanisms, developing patient stratification methods, and identifying effective drug combinations for clinical application.

Furthermore, you will be crucial in the evaluation and due diligence of external innovation opportunities.

A key task is designing and coordinating the preclinical in vivo pharmacology strategy for portfolio projects, ensuring close collaboration and alignment with the Translational Pharmacology Research Unit.

Additional key responsibilities: 



* You lead target identification and exploratory activities, moving from initial ideation to program nomination, and proactively seek future horizon opportunities while passionately co-creating new areas of focus.


* You lead high-impact, global, cross-functional portfolio projects, demonstrate resource awareness, and coordinate efforts as a matrix leader to meet long-term project objectives.


* You drive key oncology discovery efforts from bench to insight.

You design and execute sophisticated preclinical experiments, transforming complex, multi-omics data into actionable insights for target validation and understanding the mechanism-of-action (MoA) of therapeutic compounds.

You regularly present and discuss your research strategies and findings to project teams, project leaders, and key sta...