Senior Principal Scientist Pharmacology

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Please note that this role is available across multiple countries and may be posted under different requisition numbers to comply with local requirements.

While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s):

Belgium R-087821, United States of America R-108326

Remember, whether you apply to one or all of these requisition numbers, your applications will be considered as a single submission.

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Pharmacology

Job Category:
Scientific/Technology

All Job Posting Locations:
Spring House, Pennsylvania, United States of America

Job Description:

Position Title

Senior Principal Scientist Pharmacology

3Rs Portfolio Innovation and External Engagement

Location

Beerse, Belgium or Spring House, US.

Role Summary

The Sr.

Principal Scientist & SIS Scientific Lead is a senior scientific role within Scientific & In Vivo Strategies (SIS), responsible for driving the identification and enablement of 3Rs innovation opportunities into the discovery and preclinical portfolio, including new approach methodologies (NAMs).

Operating within the enterprise 3Rs framework and aligned with Discovery, Product Development & Supply (DPDS), PSTS (Preclinical Safety and Translational Sciences), and SIS strategic priorities, this role brings deep NAMs expertise (i.e., refined in vivo , ex vivo , complex in vitro models (CIVMs)/microphysiological systems (MPS)/organoids, and/or in silico approaches) to enable portfolio‑relevant 3Rs innovation that strengthens discovery and preclinical assessment and improves preclinical-to-clinical translatability while advancing 3Rs objectives.

The individual will serve as a NAMs subject‑matter expert for SIS, DPDS, and Therapeutic Area stakeholders, ensuring that both internal and external NAM opportunities are identified and evaluated through portfolio‑relevant, translational, and regulatory‑aligned perspectives.

Primary Responsibilities:

NAMs Scientific Engagement and Portfolio Integration:


* Engage with fellow SIS Scientific Leads and sta...