Principal Scientist, Data Science

At Johnson & Johnson,we believe health is everything.

Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world.

We provide an inclusive work environment where each person is considered as an individual.

At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:
Data Analytics & Computational Sciences

Job Sub Function:
Data Science

Job Category:
Scientific/Technology

All Job Posting Locations:
Cambridge, Massachusetts, United States of America, Raritan, New Jersey, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America

Job Description:

J&J Innovative Medicine - Data, Data Science, and AI - Global Development (DDSAI GD) is recruiting a Principal Scientist.

The ideal candidate will Lead analytics, ML, optimization, and GenAI that rely primarily on real‑world data to inform clinical trial design, feasibility, and execution facilitation, translate insights from RWD sources (e.g., EHR, claims, registries, digital health) into clear recommendations that shape protocol decisions and operational plans.

J&J Innovative Medicine develops treatments that improve the health of people worldwide.

Research and development areas encompass oncology, cardiovascular and metabolic disorders, immunology, pulmonary hypertension, neuroscience, and infectious disease.

Our goal is to help people live longer, healthier lives.

We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market - from patients to practitioners and from clinics to hospitals.

To learn more about J&J Innovative Medicine, visit https://www.jnj.com/innovative-medicine

Key responsibilities:


* Use RWD to quantify disease prevalence, care pathways, and the impact of inclusion/exclusion criteria; produce feasibility scoring across geographies, sites, and subpopulations.


* Assess RWD‑feasible endpoints and proxies; evaluate availability, completeness, quality, and signal‑to‑noise to guide protocol design choices.


* Construct RWD‑based cohorts and external/synthetic controls to benchmark protocol decisions and stress‑test sample‑size/timeline assumptions.


* Develop ML and multi‑objective optimization solutions primarily powered by RWD to surface trade‑offs (speed, quality, cost, diversity) and recommend design and operational scenarios informed by realâ€...