Postdoctoral Scholar, Bioanalytical Discovery and Development Sciences

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Career Programs

Job Sub Function:
Post Doc – Drug Discovery & Pre-Clinical/Clinical Development

Job Category:
Career Program

All Job Posting Locations:
La Jolla, California, United States of America

Job Description:

About Innovative Medicine:
 

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Postdoctoral Scholar, Bioanalytical Discovery and Development Sciences to be onsite in La Jolla, CA.
 

Purpose:
The Bioanalytical Discovery and Development Sciences (BDDS) team in Preclinical Sciences and Translational Safety (PSTS) develops and applies bioanalytical assays across various technical platforms to evaluate drug candidates and assess safety and efficacy biomarkers in biological matrices. 
We are seeking a highly motivated postdoctoral researcher to collaborate with industry experts and leverage innovative technologies to develop non-invasive safety biomarkers for drug development.
 

Drug-induced vascular injury (DIVI) represents a significant challenge in drug development, often leading to preclinical attrition and clinical adverse events due to the vascular system's unique vulnerability and critical physiological role.

Traditional biomarker methods often lack the sensitivity and specificity needed for early detection and mechanistic insights.

Addressing this unmet need, novel bioanalytical approaches like immunoassay-liquid chromatography/mass spectrometry (IA-LC/MS) show promise for enhancing safety biomarker quantification and mechanistic exploration.
 

The successful candidate will evaluate the feasibility and utility of IA-LC/MS to measure vascular safety biomarkers, optimize methodologies for bioanalytical applications, and investigate the biological performance of these biomarkers to detect vascular toxicities in a preclinical setting.

Additionally, the candidate will explore multiplexed applications to enable simultaneous detection and characterization of multiple biomarkers, enhancing the ability to gain comprehensive insights into complex biological processes and to...