Senior Scientist, Bioanalysis - Cellular Immunogenicity

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Pharmacokinetics & Pharmacometrics

Job Category:
Scientific/Technology

All Job Posting Locations:
Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Johnson & Johnson Innovative Medicine R&D is recruiting for a Senior Scientist, Bioanalysis - Cellular Immunogenicity located in Spring House, PA.

The Bioanalytical Discovery and Development Sciences (BDDS) organization develops, validates, and conducts bioanalytical sample analysis across the entire J&J Innovative Medicines (JJIM) R&D portfolio from discovery through development.

 We are looking for an accomplished and dedicated Senior Scientist to design and perform cellular immunogenicity assays within BDDS for Johnson & Johnson portfolio projects spanning all modalities and therapeutic areas from nonclinical studies to post-market clinical development.

Principal Responsibilities:


* Independently lead and perform the design, method development, validation, Good Laboratory Practices (GLP)/Good Clinical Laboratory Practice (GCLP) bioanalysis and reporting for various cellular immunogenicity assays, including ELISpot, multiplex FluoroSpot, multi-parametric flow cytometry, multiplex cytokine assays, innate immune response assays etc.

to assess preclinical and clinical safety and efficacy of various Johnson & Johnson modalities and programs, including gene therapy, cell therapy, therapeutic vaccines, siRNA, therapeutic antibodies, etc.


* Evaluate and develop new methodologies for innate and adaptive cellular immunogenicity testing and perform optimization and troubleshooting of current methods and processes.


* Help oversee Peripheral Blood Mononuclear Cells (PBMC) processing and cellular immunogenicity assays for outsourced projects and interprets experimental results from Contract Research Organizations (CROs).


* Familiar with the in-silico tools; in vitro and ex vivo assays for immunogenicity risk assessments o...