Principal Scientist, Radiochemist (Discovery Chemistry)

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Chemical Research

Job Category:
Scientific/Technology

All Job Posting Locations:
Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Principal Scientist, Radiochemist (Discovery Chemistry) to be onsite in Spring House, PA. 
 

Purpose:
The Radiochemist will be a technical expert in the discovery and development of radiolabeling chemistries that produce targeted radiotherapeutics.

They will work independently in collaboration with cross functional discovery teams, early and late development organizations, and external partners (C(D)MOs) to facilitate the successful discovery and development of next-generation Radiotherapeutics, and radiopharmaceutical manufacturing processes for clinical and commercial development.
 

You will be responsible for:
•    Make significant contributions at the program team level around radiopharmaceutical design based on the target and develop new radiolabeling methodologies and formulations (to prevent/minimize radiolysis) for discovery and preclinical stage programs.
•    Evaluate novel chelator and linker combinations that incorporate therapeutic radioisotopes to drive optimal biophysical and stability properties.
•    Work closely with discovery biology, bioconjugation and PET radiochemistry teams to assist in the development of preclinical imaging tracers and companion PET diagnostics.
•    Develop novel analytical methods that are both suitable and optimized for different modality-based targeting vectors/delivery vehicles.
•    Support the filing of regulatory documents (INDs, ANDAs) for the use of the novel radiopharmaceutical and author research and development reports, manuscripts for publications and assist in patent applications.
•    Lead discussions in the transfer of radiochemistry technology, analytical procedures and proprietary techniques to internal and extern...