Senior Research Scientist – Translational Pharmacology

At Elanco (NYSE: ELAN) – it all starts with animals!

As a global leader in animal health, we are dedicated to innovation and delivering products and services to prevent and treat disease in farm animals and pets.

At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose – all to Go Beyond for Animals, Customers, Society and Our People.

At Elanco, we pride ourselves on fostering a diverse and inclusive work environment.

We believe that diversity is the driving force behind innovation, creativity, and overall business success.

Here, you’ll be part of a company that values and champions new ways of thinking, work with dynamic individuals, and acquire new skills and experiences that will propel your career to new heights.

Making animals’ lives better makes life better – join our team today!

In this non-laboratory-based (Senior) Research Scientist role in the Non-Clinical Development team, you will drive critical pharmacological strategies in early drug development to profile new chemical and biological entities and advanced therapies.

Your focus will be on mitigating clinical development risks by bridging the gap between in vitro screening and clinical efficacy.

Working as the translational representative within cross-functional teams, you will apply a deep understanding of target pharmacology and therapeutic options to advance our pipeline assets and translate findings into clinical development scenarios.

 

Study Design & Data Synthesis


* Design and coordinate translational pharmacological studies for profiling compounds.


* Analyze drug mechanisms of action, target biology, and disease pathophysiology to generate actionable insights that reduce clinical development risk.

Scientific Oversight of CROs


* Manage the integration of translational R&D by coordinating early in vivo profiling programs across involved disciplines.


* Provide technical oversight for experimental in vivo studies, ensuring the selection of suitable animal disease models for screening and dose prediction.

Biomarker & PK/PD Execution


* Define and implement in vitro and in vivo biomarker strategies for target engagement, pharmacodynamics, and safety.


* Partner with Safety and DMPK experts to initiate PK/PD approaches that provide robust scientific justification for therapeutic dosing.

Translational Analysis


* Execute reverse translational processes by performing meta-analyses of clinical data across species.


* Identify reasons for study failure, evaluate consequences for further development, and uncover new indications for existing portfolio compounds.

Matrix Representation & Scientific Leadership


* Serve as the translational pharmacology subject matter expert (SME) within a complex matrix organization.


* Collaborate with external academic and industry partners to assess in-licensed products.


* Provide clear scientific guidance to Marketing, Business Development, and...