Senior Scientist, Multiomics Discovery

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Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Biological Research

Job Category:
Scientific/Technology

All Job Posting Locations:
Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Multiomics Discovery located in Spring House, PA.

Purpose: We are seeking an accomplished Senior Scientist to develop mechanistic insights from phenotypic assays that are based in spatial omics disease maps.

The ideal candidate will lead the development of technically-complex, high‑throughput cellular assay platforms that support discovery efforts in immunology, neuroscience, and oncology.

The ideal candidate must have deep expertise in designing and constructing genetic libraries, implementing CRISPR‑based perturbation strategies, and building engineered cell systems that enable mechanistic insights and scalable experimentation.

This role offers the opportunity to shape cutting‑edge experimental platforms that drive discovery and enable the systematic exploration of complex biological systems rooted in a deep, multimodal spatial understanding of disease biology.

In this role, you will design and execute complex phenotypic assays, including FACS‑based analyses, pooled optical screening, massively parallel reporter assays (MPRA), and other multiplexed readout approaches.

You will deploy these assays across a range of primary and engineered cell types.

Experience with immune cells and advanced model systems such as iPSCs, organoids, co‑culture systems, and cell‑printing technologies is highly valuable.

You will also drive innovation in the development of perturbation libraries, optimize their delivery ...