Principal Scientist PBPK and Mechanistic Modeling

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Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Pharmacokinetics & Pharmacometrics

Job Category:
Scientific/Technology

All Job Posting Locations:
Beerse, Antwerp, Belgium

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are seeking a highly motivated talented Principal Scientist to join our Translational PBPK/PD modeling group within the Translational Pharmacokinetic Pharmacodynamic and Investigative Toxicology (TPPIT) department located in Beerse, Belgium.

The successful candidate will work on mechanistic modeling questions to enable strong decision-making in the selection of promising candidate drugs and associated dosing regimens at the interface of pre-clinical/clinical development.

In this role, the candidate will develop and apply innovative mechanistic translational modeling strategies that integrate in vitro, in vivo, pharmacokinetic, pharmacodynamic, efficacy and safety data across emerging therapeutic modalities.

Model predictions will be ultimately verified with clinical PK, PD, efficacy and safety datasets.

A close collaboration with clinical pharmacology and pharmacometrics experts, in vitro and in vivo scientists, is expected.

The candidate will be authoring scientific reports, internal and external presentations, and peer-reviewed publications.

Experience and Skills:

Qualifications / Requirements:

Required:


* PhD in a relevant life science subject area (pharmacokinetics, pharmacometrics, biomedical engineering, systems pharmacology) or a related field with 3+ years of relevant industry experience is required with strong expertise in PBPK or mechanistic PK/PD modeling.


* Hands-on experience with translational modeling, Physiological-Based Pharmacokinetic (PBPK) modeling i...