Principal Scientist, Vector Biology

At Johnson & Johnson,we believe health is everything.

Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world.

We provide an inclusive work environment where each person is considered as an individual.

At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Biological Research

Job Category:
Scientific/Technology

All Job Posting Locations:
Cambridge, Massachusetts, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Principal Scientist, Vector Biology to be in Cambridge, MA.

Purpose:

We are seeking a Principal Scientist to spearhead receptor and viral‑entry biology initiatives that translate mechanistic insight into therapeutic progress.

Responsibilities include creating and validating cell‑based assays for receptor localization and ligand/virus binding, dissecting entry pathways, and optimizing lentiviral transduction in coordination with cross‑functional teams.

You will be responsible for:


* Lead and contribute to research focused on the cellular and molecular mechanisms of enveloped virus entry.


* Design and execute experiments to characterize the interactions between viral glycoproteins and host cell receptors.


* Design, develop, and validate robust cell-based assays probing: receptor expression/localization and ligand/virus binding; internalization/endocytosis pathways; functional readouts by flow cytometry, high‑content/fluorescence microscopy, and reporter assays.


* Utilize lentiviral vector systems to study the transduction of target cells and to develop novel gene delivery platforms.


* Establish scalable, reproducible workflows and SOPs; implement assay performance criteria and QC.


* Integrate data with cross-functional partners (protein/vector engineering, analytics, translational, process/CMC) to inform target selection, vector design, and process improvements.


* Present research findings at...