DMPK-PD Project Leader (2-year temporary position)

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Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.

This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.

Join Roche, where every voice matters.

The Position

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs.

At pRED, we are united by our mission to transform science into medicine.

Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

pRED's Pharmaceutical Sciences (PS) group enables discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines.

PS supports discovery and development across the whole value chain from target assessment to on-market and beyond.

The Opportunity

As part of the Translational DMPK-PD and Clinical Pharmacology chapter, you will focus on providing the right drug at the right dose to patients safely with an efficacious benefit.

You will collaborate closely with therapeutic areas to convert hypotheses into innovative medicines, driving nonclinical strategies to bring forward the best clinical candidates for specific indications.

Your Impact & Responsibilities:



* Strategy & Design: Lead drug design and optimization strategies and compound profiling for all Drug Metabolism and Pharmacokinetics (DMPK) aspects, with a strong focus on target biology validation and translational PK/Pharmacodynamics (PD) concepts.


* Translational Evaluation: Provide support to early discovery teams in the development of translational strategies for the clinical evaluation of target modulation through the application of biochemical and pharmacological considerations.


* Modeling & Simulation (M&S): Execute fundamental M&S activities, including PKPD, Physiologically-Based Pharmacokinetics (PBPK), Drug-Drug Interaction (DDI), and human dose/regimen prediction, to provide essential support for projects spanning from Lead Optimization (LO) through Entry into Human (EIH).


* Regulatory Support: Prepare and deliver high-quality scientific assessments of non-clinical DMPK information for internal program reviews and external regulatory submissions (e.g., Investigational New Drug (IND), Investigator's Brochure (IB), Clinical Trial Application (CTA), New Drug Application (NDA), Biologics License Application (BLA)).


* Implementation: Implement biomark...