Formulation Development Intern

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Career Programs

Job Sub Function:
Non-LDP Intern/Co-Op

Job Category:
Career Program

All Job Posting Locations:
Malvern, Pennsylvania, United States of America

Job Description:

This project will study effect of different real-world stresses on drug products in the J&J portfolio.

Experiments will be designed and executed to mimic the intensity and duration of agitation that protein formulations experience during transportation in vials, IV bags, and syringes.

A fundamental understanding of the impact of physical stresses on protein formulations will be gained by a thorough literature review as well as experimental data collection. 

A safe and effective drug product must be able to withstand a variety of different forces experienced during shipping, preparation, and administration.

These forces include shear stress, mixing stresses, impact stresses (i.e.

drop stress), and cavitation.

Therapeutic proteins are inherently sensitive to these stresses and may form insoluble aggregates that can impact patient safety.

During formulation selection, drug products are exposed to some of these stresses in bench-top shaking studies, however there is little understanding of how well these lab-based studies mimic the stresses during real shipping and transport.

New studies have provided measurements of the duration and intensity of the real-world stresses experienced during transportation and have they depend on the acceleration and geometric orientation of the stress relative of the drug product.

All of these stresses cannot be captured on a standard bench-top shaking plate, therefore a gap exists between developmental studies and real-world.

This project will include the design of new bench-top studies in order to separately study the effects of mixing stress, shear stress, extensional stress and air-entrainment and utilization of particle characterization tools like dynamic light scattering (DLS), Flowcam, and MFI.

By developing a comprehensive stress-specific framework for studying protein formulations, a better understanding of how different real world stresses impact drug product stability can be captured.  The findings and outcomes from this project will be leveraged across all protein formulations for conducting shaking studies to ensure product stability and patient safety.  

Majors: Chemistry, Chemical Engineering, Pharmaceutical Sciences, Biochemistry, Biomedical Engineering

Prerequisites (prio...