Principal Scientist, Large Language Reasoning - Drug Discovery

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Data Analytics & Computational Sciences

Job Sub Function:
Data Science

Job Category:
Scientific/Technology

All Job Posting Locations:
Berlin, Germany, Cornellà de Llobregat, Barcelona, Spain, Madrid, Spain, NEUSS, Germany

Job Description:

Johnson & Johnson Innovative Medicine (J&J IM) is recruiting for the role of Principal Scientist – Large Language Reasoning for Drug Discovery.

The primary location for this role is Barcelona / Madrid, Spain with secondary location being considered in Germany.

J&J IM develops treatments that improve the health and well-being of people worldwide.

Research and development areas encompass oncology, cardiovascular and retina disorders, immunology, and neuroscience.

Our goal is to help people live longer and healthier lives.

We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners and from clinics to hospitals.

To learn more about J&J IM, please visit https://www.jnj.com/.

The Machine Intelligence (MI) team within Data Science and Digital Health (DSDH) AI/ML is seeking a visionary Principal Scientist to architect autonomous AI in drug discovery and development.

You'll pioneer innovative work with Large Language Models (LLMs) and agentic systems, harnessing large scale datasets spanning scientific literature, omics, biomolecular knowledge, and manufacturing processes to fundamentally transform how we bring therapeutics to patients.

Your innovations in areas such as multimodal reasoning, agent adaptability and uncertainty, memory architecture, and motivation frameworks will directly compress discovery timelines and accelerate promising therapeutics from hypothesis to clinical trials.

Key Responsibilities:



* Pioneer breakthrough multimodal AI systems that synthesize scientific data into actionable scientific insights which accelerate drug discovery


* Architect next-generation agent memory systems that establish how AI retains knowledge and makes context-aware decisions, creating persistent intelligence that evolves across the entire discovery-to-development pipeline


* Define the future of AI reliability in R&D by orchestrating groundbreaking research in uncertainty quantification and establishing new standards for trustworthy AI-driven scientific reasoning


* Shape the scientific vision as an inspiring leader, translating emerg...