Principal Scientist, Developmental and Reproductive Toxicology (DART)

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Nonclinical Safety

Job Category:
Scientific/Technology

All Job Posting Locations:
Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Principal Scientist, Developmental and Reproductive Toxicology (DART) to be onsite in Spring House, PA.
 

Purpose:
This Principal Scientist, Developmental and Reproductive Toxicologist (DART), in Nonclinical Safety and Submissions (NCSS), a department in the Preclinical Sciences and Translational Safety (PSTS) organization within Janssen Research & Development (R&D), functions as a scientific subject matter expert, providing guidance on DART and juvenile toxicity strategy, risk assessment, and communication across various therapeutic areas.

The position involves application of the 3Rs through leveraging existing data/knowledge for weight-of-evidence approaches and exploring NAMs in lieu of in vivo studies.

The applicant's demonstrated experience, skills, and competencies relevant to the position's complexity and responsibilities has the potential to influence the grade of the position. 

You will be responsible for:


* Provide subject matter expertise in reproductive, developmental, & juvenile toxicology to global multi-disciplinary teams within PSTS supporting drug development programs. 


* Engagement in DART target risk assessments and guide DART and juvenile toxicity strategy for biologics, small molecules, and other modalities.   


* Maintain up-to-date knowledge regarding innovative approaches in (predictive/alternative/NAMs) DART research and possibilities to support DART risk assessment. 


* Assist with preparation of DART-related sections for health authority submissions, (i.e., marketing authorizations, pediatric plans, briefing books detailing weight-of-evidence approaches) and responses to questions. 


* Design of DART and juvenile toxicity studies for various ...