Principal Scientist pharmacokinetic/pharmacodynamic modeling expert

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Pharmacokinetics & Pharmacometrics

Job Category:
Scientific/Technology

All Job Posting Locations:
Beerse, Antwerp, Belgium

Job Description:

We are searching for a talented Principal Scientist pharmacokinetic/pharmacodynamic modeling expert in Translation Pharmacokinetic Pharmacodynamic and Investigative Toxicity (TPPIT) group within Preclinical Safety and Translational Sciences (PSTS), to be located in Beerse, Belgium.

The successful candidate will be employed within our PBPK/PD modelling team in TPPIT.

Key responsibilities:



* Represent PSTS/TPPIT as pharmacokinetic/pharmacodynamic modelling expert in cross-functional project teams and external collaborations


* Independently, develop and apply PBPK/PD models to explore the effects of target and pathway modulation, defining candidate drug target profiles and projection of human exposure profiles.


* Predict human dose and regimen, contribute to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials.


* Interpret and communicate modelling results and impact to project teams


* Designs, conducts, interprets and prepares study and regulatory summaries of PBPK and PKPD M&S activities


* Prepare PBPK and/ PKPD M&S-based strategies to support discovery and development programs


* Drive learning through back-translation of clinical exposure and pharmacodynamic data, offering strategic options for future clinical testing.


* Acts as a main contact for team members in discussions relating to the design of their studies and data analysis to support, clinical candidate selection, development and approval of medicines


* Guides junior colleagues through consultation and mentoring in techniques and processes, and provides functional (matrix) supervision

You will be encouraged to have a desire for learning and innovation, and to continue career development through participation in internal and external scientific meetings, and increase visibility for self, J&J IM R&D, and J&J through publications, participation in external organizations, and presentations at major scientific, industry, and regulatory meetings.

Qualifications / Requirements:

Required:


* PhD in a relevant life science subject area, e.g.

pharmaceutical sciences, pharmacometrics, computational biology, chemical/biomedical engineering, or a related field
...