Scientist, Synthetic Biology - Genomic Medicine

At Roche you can show up as yourself, embraced for the unique qualities you bring.

Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.

This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.

Join Roche, where every voice matters.

The Position

A healthier future.

It’s what drives us to innovate.

To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come.

Creating a world where we all have more time with the people we love.

That’s what makes us Roche.

In Roche´s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs.

At pRED, we are united by our mission to transform science into medicine.

Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The Therapeutic Modalities (TMo) function is part of the Roche Pharma Research and Early Development (pRED) organization.

TMo discovers and optimizes innovative drug candidates including small molecules, biologics and nucleic acid-based therapeutics with the goal of delivering novel therapeutic approaches across all pRED Discovery and Translational areas (DTAs).

We are seeking a Scientist in Synthetic Biology with a strong background in recombinant adeno-associated virus (rAAV) gene therapies to join the Nucleic Acid-Based Medicine (NABM) group within the TMo division at pRED.

As a member of NABM, you will collaborate with a diverse group of experts, committed to pioneering the next generation of viral and non-viral gene therapies, utilizing design-build-test-learn (DBTL) cycles to drive innovation.

Together, we cultivate a vibrant and collaborative community, continually exploring and implementing innovative approaches in our research environment.

 

The Opportunity

Your role will focus on designing and testing genetic elements utilizing synthetic biology techniques and expertise to advance the development of novel AAV-based gene therapies.

You will also work in the wet lab to test and identify lead molecules for further development in the drug discovery pipeline.

Your impact:


* You design, build, test and develop novel gene therapy payloads using computational tools and AI/ML models, focusing on large pooled library design to address disease targets.


* You collaborate closely with disease experts to integrate genetic, RNA, and protein elements into functional synthetic systems in mammalian cells.


* You apply advanced genome editing and cell engineering technologies to generate tailor-made cell lines for assa...