Senior Scientist (Synthetic Chemist)

Kyfora Bio, the bioprocessing brand of Polysciences, advances cell and gene therapy innovation through specialized transfection reagents and excipients designed for viral vector and mRNA delivery systems.

Leveraging over six decades of chemical R&D and manufacturing experience, Kyfora offers scalable, cGMP-compliant solutions that support the entire development lifecycle—from bench to clinic—enabling next-generation therapies to reach patients efficiently and safely.

Summary of Position

Kyfora Bio seeks a highly motivated and detail-oriented Synthetic Organic Chemist (M.S.

degree or higher) to join our R&D team.

The role involves designing, synthesizing, purifying, and characterizing organic molecules, monomers, and polymers engineered for drug delivery, including transfection reagents.

The candidate will work closely with the R&D team leader and VP to support early-stage development, process optimization, and technology transfer to manufacturing.

A strong background in synthetic organic chemistry (lipid and polymer experience preferred), familiarity with cGMP principles, and the ability to efficiently execute and document lab-scale reactions under tight timelines are essential.

Essential Functions

1.

Synthesis & Process Development


* Conduct lab-scale synthesis of drug delivery agents such as polycations, lipids, reactive monomers, and polymers.


* Optimize reactions to improve yield, purity, and scalability.


* Plan and perform multi-step syntheses and polymerizations, including air-sensitive techniques when needed.


* Develop synthetic routes for consistent product quality at scale.

2.

Purification & Characterization


* Purify products using chromatography, precipitation, dialysis, or crystallization.


* Monitor reactions and characterize compounds using analytical tools (NMR, FTIR, GPC, HPLC, GC, MS, UV-Vis, Karl Fischer titration).


* Troubleshoot synthesis and purification issues through literature research and collaboration.


* Familiarity with Dynamic Light Scattering (DLS) and Zeta Potential analysis (Zeta Sizer) for formulation characterization is a plus.

3.

Documentation & Batch Records


* Maintain detailed laboratory notebooks with precise experimental data, following Good Documentation Practices (GDP).


* Draft and revise batch records, SOPs, and technology transfer documents for scale-up and cGMP production.


* Work closely with QC to review records and analytical data for validation readiness.


* Contribute to Chemistry sections of development and regulatory reports.


* Ensure traceability and audit compliance of documentation.

4.

Project Support & Technology Transfer


* Collaborate with formulation, QC, process engineering, and biology (transfection) teams to meet project milestones.


* Provide technical support during process transfers and scale-up.


* Adapt lab procedures for pilot and production environments.

5.

Time & Resource Management


* Man...