Sr. Scientist PSTS Transl. PK

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Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Pharmacokinetics & Pharmacometrics

Job Category:
Scientific/Technology

All Job Posting Locations:
Beerse, Antwerp, Belgium

Job Description:

We are currently seeking a Senior Scientist to join our Global Translational ADME group, an area within the Translational Pharmacokinetics (PK)/Pharmacodynamics (PD) & Investigative Toxicology (TPPIT) department.

Our global translational ADME team is committed to providing project teams with mechanistic insights and integrating data to understand the correlations between in vitro and in vivo ADME properties, as well as the interplay between PK, toxicokinetics and PD responses.

The Translational ADME team in Beerse is looking for a highly motivated individual to pioneer and implement New Approach Methodologies (NAMs), including organotypic in vitro models that emulate organ biology to enable comprehensive PK/PD and safety characterization within a singular in vitro system (“PK/PD in a dish”).

In this role, you will be supporting the ADME, efficacy, and safety profiling of small molecules and modalities such as antibody drug conjugates (ADCs), peptides, proteolysis targeting chimeras (PROTACs), and antibodies.

The successful candidate will play a key role in establishing workflows to determine the therapeutic exposure in a patient centric manner by establishing next generation complex in vitro models and in silico approaches.

Strong subject matter expertise and hands-on experience with organoids, tumoroids, bio-printed platforms are expected, and co-culture models with immune cells.

This position will require hands-on lab work, while also offering ample scientific leadership and personal growth opportunities through training, mentoring and R&D-wide connectivity.

Additionally, you will be authoring reports and scientific publications and present data to the scientific community both internally and externally.

Required Knowledge, Skills, and Abilities:


* Education: PhD degree in a relevant life science discipline (e.g.

cellular biology, immunology, biomedical sciences or similar) with a preference for candidates with postdoctoral experience.



* Technical Expertise: Strong theoretical knowledge and practical experience in culturing organotypic models (organoids, tumoroids, bio printed platforms, co-culture models with immune cells).


* Methodological Skills: A broad range of hands...