Postdoctoral Scholar, Oligochemistry

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Career Programs

Job Sub Function:
Post Doc – Drug Discovery & Pre-Clinical/Clinical Development

Job Category:
Career Program

All Job Posting Locations:
San Diego, California, United States of America

Job Description:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

J&J IM is seeking a highly motivated postdoctoral scholar specialized in Oligonucleotide chemistry to join our fast-paced Cell and Genetic Medicine Team in San Diego, California.

Purpose:

The Postdoctoral Scholar, Oligochemistry will work cross-functionally in the Therapeutics Discovery organization to broaden the use of RNAi into extrahepatic tissues.

The successful candidate will be responsible for the design, synthesis, purification and characterization of chemically modified, therapeutic oligonucleotides.

The postdoctoral scholar will collaborate with assay development and biology teams within the RNA therapeutics and delivery group in La Jolla and employ molecular modeling and high resolution imaging approaches within the global J&J organization.

 

You will be responsible for:


* Drive innovation in oligonucleotide chemistry includes design, solid phase synthesis, and characterization of novel oligonucleotide structures to improve potency and durability


* Expert in operating instruments and equipment including MerMade, Dr.

Oligo, AKTA pure, HPLC, LC-MS, and UV/Vis


* Independently problem-solve in the laboratory setting to overcome synthetic challenges as well as  adapt and improve upon existing workflows


* Partner with cross-functional teams within the global J&J organization


* Review and stay current on scientific literature and apply novel solutions and strategies to establish novel chemical modification schemes balancing bioavailability, delivery, tolerability and potency.


* Development, training, conferences, internal meetings & symposia

Education and Experience:


* Required Minimum Education: PhD


* PhD in organic chemistry or related scientific discipline


* Preferred Areas of Study-oligonucleotide chemistry and anal...