RPF Post Doctorate Scientist - 3D Segmentation of Organoids

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The Position

We advance science so that we all have more time with the people we love.

The position 

As a Postdoctoral Fellow (m/f/d) in the Roche Pharma Research and Early Development Data and Analytics Department, you will focus on developing novel methods for 3D segmentation of organoids, morphology analysis, and cell identification in tandem with the Immune & Cell Biology department in Large Molecule Research (LMR). 

 

You will work with a team of experienced scientists and biologists to develop computer vision models focusing on biological insights.

These models will enable label-free detection and tracking of cell types in 3D organoid models, enhancing our understanding of cellular dynamics and morphology.

This innovative approach will support ongoing efforts in various therapeutic areas by improving cellular composition and organoid variability analysis.

By leveraging advanced imaging techniques and AI, this project aims to accelerate the development of targeted therapies and optimize drug screening processes, ultimately contributing to Roche's commitment to pioneering advancements in healthcare.

The role involves developing an AI-driven image analysis pipeline to enable the study of 3D biological models, leading to a deeper understanding of the mode of action of therapeutic molecules.

This initiative focuses on detecting and tracking cell types without the need for fluorescent labels, utilizing advanced imaging techniques.

The project aims to automate the analysis of large 3D imaging datasets, addressing a significant bottleneck in research and accelerating the development of targeted therapies.

By establishing a comprehensive imaging pipeline, the workflow will enable live readouts and detailed characterization of cellular composition and states over time.

This approach is expected to significantly impact the screening and characterization of therapeutic AAV vectors, ultimately contributing to improved drug discovery.

The position is sponsored by the Roche Postdoctoral Fellowship (RPF) Programme, which aims to build and maintain the scientific leadership of the future and provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers and leading academic research groups worldwide.

One key aim is to advance fundamental science and technologies, which will be published in top-rated, peer-reviewed scientific journals, if necessary, and preceded by priority patent applications.

As a postdoctoral fellow (m/f/d), you will be supervised by scientists at Roche and an independent academic expert as a partner.

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