Senior Scientist, CAR Screening and Lead Selection (Cell & Genetic Medicines Discovery)

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Biotherapeutics R&D

Job Category:
Scientific/Technology

All Job Posting Locations:
Cambridge, Massachusetts, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for two Senior Scientist, CAR Screening and Lead Selection (Cell and Genetic Medicines Discovery) that will be based in Cambridge, MA.

Purpose:

We are seeking a highly motivated and technically skilled Senior Scientist to join our CAR Screening and Lead Selection team focused on advancing next-generation cell therapies.

The Senior Scientist will design, execute, and analyze in vitro assays to characterize CAR-T candidates, supporting data-driven decisions that drive pipeline progression.

This role offers the opportunity to work cross-functionally in a dynamic, fast-paced environment with cutting-edge technologies.

Responsibilities:


* Design, perform, and troubleshoot complex in vitro assays, including flow cytometry-based immunophenotyping and functional assays to evaluate CAR-T activity.


* Develop and execute IncuCyte-based cytotoxicity assays to assess cell killing and persistence.


* Maintain meticulous records of experimental design, data, and analysis using Benchling electronic lab notebook (ELN).


* Analyze and visualize complex datasets using GraphPad Prism and other visualization tools; clearly communicate results in team meetings and reports.


* Collaborate closely with colleagues in discovery, process development, and therapeutic area teams to align priorities and share data.


* Contribute to experimental design discussions and provide technical guidance to junior team members.


* Ensure laboratory operations follow best practices for safety, data integrity, and reproducibility.

Qualifications:


* PhD in immunology, cell biology, or a related field with 2+ years of relevant industry or postdoctoral experience; OR a BS or MS with 4-6 years of experience will also be c...